s/brian_armstrongPEPTIDE STACKS•Apr 22
142
votes
9.5k
seen
Bryan Johnson sees REM sleep drop ~40% two nights into CJC-1295 DAC
Stacking a GH peptide against a GLP-1 to cancel side effects hit a snag almost immediately. Two nights into CJC-1295 DAC, sleep fell apart, with REM down ~40% from a two‑week baseline while deep sleep held. This comes right after moving from debating DAC vs no‑DAC into a live four‑week protocol that adds tirzepatide later.
• Weekly CJC-1295 DAC, then tirzepatide 0.25 mg twice weekly in weeks 3-4; prior tirzepatide at 0.5 mg/week raised resting HR by 2-3 bpm
• Continuous CGM, 24/7 sleep/HR/HRV, weekly labs (IGF-1, GH, fasting glucose, insulin, HOMA-IR), plus core temp
The idea is opposing effects: tirzepatide improves glucose but nudges HR up, while CJC-1295 boosts GH/IGF-1 but worsens insulin resistance. He said he'll compare a full post‑CJC week to baseline and abort or switch to no‑DAC CJC-1295 plus ipamorelin if the sleep disruption persists.
• Weekly CJC-1295 DAC, then tirzepatide 0.25 mg twice weekly in weeks 3-4; prior tirzepatide at 0.5 mg/week raised resting HR by 2-3 bpm
• Continuous CGM, 24/7 sleep/HR/HRV, weekly labs (IGF-1, GH, fasting glucose, insulin, HOMA-IR), plus core temp
The idea is opposing effects: tirzepatide improves glucose but nudges HR up, while CJC-1295 boosts GH/IGF-1 but worsens insulin resistance. He said he'll compare a full post‑CJC week to baseline and abort or switch to no‑DAC CJC-1295 plus ipamorelin if the sleep disruption persists.
Timeline3
Apr 16
Johnson outlined the stacking hypothesis and debated CJC-1295 DAC versus no-DAC plus ipamorelin with his clinical team.
Apr 21
Johnson said he was starting the four-week protocol with weekly CJC-1295 DAC and low-dose tirzepatide added in weeks 3 and 4.
Apr 22
Johnson reported sleep disruption after two nights on CJC-1295 DAC and said he may abort or switch protocols if it continues.
1 comment
Apr 22